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KMID : 1123920020160061277
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1277 ~ p.1283
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Effect of Silsosangami on Platelet Aggregation, Hemolysis and Inducible Nitric Oxide Synthase
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Kim Chang-Hwan
Kim Han-Geu
Ahan Jong-Chan
Lee Soo-Kyung
Chung Tae-Wook
Kim June-Ki
Choi Dall-Yeong
Kim Cherl-Ho
Park Won-Hwan
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Abstract
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Silsosangami(SSG) is a formula of treaditional korean medicines as an effective biological response modifier for augmenting host homeostasis of body circulation. Little is known of the biological activity of SSG and previous studies have focused mainly on their anti-thrombosis8). There is a growing interest in the pharmacological potential of the SSG due to the recent finding by our group that SSG and each constituent herbs of SSG were able to inhibit NO and prostaglandin E2 (PGE2) synthesis in murine peritoneal macrophages stimulated with bacterial endotoxin. In this paper, the effects of SSG on platelet aggregation and hemolysis in human blood were studied. SSG provoked remarkable inhibiting effect on platelet aggregation, and APTT were sensitive to the presence of this SSG. Using an in vitro system, APTT was delayed with the increment of the concentrations of these seven compounds. These results suggested that SSG might be used as a novel antithrombotic therapeutic agents in post-myocardial infarction. A SSG reduced NO production in mouse peritoneal macrophages stimulated with lipopolysaccharide, without the influence on the activity of iNOS being observed. SSG significantly reduced mouse paw edema induced by carrageenan. Western blot analysis showed that SSG reduced the expression of iNOS. The results indicate that SSG exerts anti-inflammatory effects related to the inhibition of NO production, which could be due to a decreased expression of iNOS.
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KEYWORD
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Silsosangami(失笑散加味), platelet aggregation, prostaglandin E2, iNOS
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